期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 42, 页码 36665-36674出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b12949
关键词
polyimide; reduced graphene oxide; gold nanoholes; photothermal therapy; bacteria ablation; wound infection; in vivo treatment
资金
- Centre National de la Recherche Scientifique (CNRS)
- University Lille 1
- Hauts-de-France region
- CPER Photonics for Society
- Agence National de la Recherche (ANR) through FLAG-ERA JTC-Graphtivity
- EU union through the Marie Sklodowska-Curie action (H-MSCA-RISE) [PANG 690836]
- Belgian F.R.S. - FNRS [T.1004.14, R 50.02.16.F]
Despite the availability of different antibiotics, bacterial infections are still one of the leading causes of try hospitalization and mortality. The clinical failure of antibiotic treatment is due to a general poor antibiotic penetration to bacterial infection sites as well as the development of antibiotic-resistant pathogens. In the case of skin infection, the wound is covered by exudate, making it impermeable to topical antibiotics. The development of a flexible patch allowing a rapid and highly efficient treatment of subcutaneous wound infections via photothermal irradiation is presented here. The skin patch combines the near-infrared photothermal properties of a gold nanohole array formed by self-assembly of colloidal structures on flexible polyimide films with that of reduced graphene oxide nanosheets for laser-gated pathogen inactivation. In vivo tests performed on mice with subcutaneous skin infection and treated with the photothermal skin patch show wound healing of the infected site, while nontreated areas result in necrotic muscular fibers and bacterial infiltrate. No loss in efficiency is observed upon multiple use of these patches during in vivo experiments because of their robustness.
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