期刊
GENOME BIOLOGY
卷 18, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13059-017-1347-3
关键词
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资金
- NHMRC [1102006]
- Cancer Council Victoria
- Victorian Cancer Agency Mid Career Research Fellowship
- Victorian State Government OIS
- NIH [R01GM102484, R01GM104215, R01MH115080]
- Ellison Medical Foundation
- Stanford University Department of Genetics
- National Health and Medical Research Council of Australia [1102006] Funding Source: NHMRC
One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.
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