期刊
BIOMATERIALS
卷 146, 期 -, 页码 115-135出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.09.004
关键词
Biological process; Diagnosis; Theranostics; Aggregation-induced emission; AIE
资金
- Innovation and Technology Commission [ITC-CNERC14SC01]
- National Basic Research Program of China (973 Program) [2013CB834701, 2013CB834702]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- Research Grants Council of Hong Kong [16305015, 16308016, C2014-15G, N-HKUST604/14, AHKUST605/16]
- Guangdong Innovative Research Team Program of China [201101C0105067115]
- Science and Technology Plan of Shenzhen [JCYJ20160229205601482]
- Shenzhen Peacock Plan
Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseases, precisely guiding therapeutic effect in theranostics. It largely relied on fluorophores with the properties of excellent photostability, large Stokes shift, high signal-to-noise ratio and free of aggregation-caused quenching (ACQ) effect. Luminogens with aggregation-induced emission characteristic (AlEgens) could serve as superior agents for biological process monitoring and disease theranostics. Herein, we review the recent results in the aspects of monitoring biological processes such as autophagy, mitophagy, mitochondrion-related dynamics, cell mitotic, long-term cellular tracing and apoptosis as well as the diagnosis of related diseases based on AlEgens in real time. As part of AlEgens and AlEgen-based nanoparticles with the functionalities of drugs, photosensitizers and adjuvants accompanied with imaging, they exhibit huge potential in theranostic systems for image-guided chemotherapy, photodynamic therapy, radiotherapy and so on. Collectively, these examples show the potentials of AlEgens for understanding disease pathogenesis, for drug development and evaluation, and for clinical disease diagnosis and therapy. Future research efforts focused on developing long-wavelength excitable and phosphorescence-emissive AlEgens with improved depth-penetration and minimized background interference for fluorescence and photoacoustic imaging, will extend the potential applications of AlEgens in in vivo. (C) 2017 Elsevier Ltd. All rights reserved.
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