期刊
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
卷 477, 期 1, 页码 401-404出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1607672917060151
关键词
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资金
- Russian Science Foundation [17-14-01353]
- Russian Foundation for Basic Research [16-34-01216-mol-a]
- Russian Science Foundation [17-14-01353] Funding Source: Russian Science Foundation
The developing thymus of rat fetuses contains all components of the serotonergic system: receptors, enzymes of synthesis, and membrane transporters. The expression of receptors suggests the possibility of a direct influence of serotonin on thymic development. The presence of tryptophan hydroxylase (the key rate-limiting enzyme of serotonin synthesis) and aromatic l-amino acid decarboxylase indicates the ability of fetal thymic cells to synthesize serotonin. It was shown that the cells of a developing thymus can actively uptake extracellular monoamines. The results of this study suggest different functions of the intrathymic and circulating serotonin pools in the regulation of thymic development.
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