期刊
NATURE REVIEWS IMMUNOLOGY
卷 17, 期 11, 页码 703-717出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.75
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资金
- Bloomberg-Kimmel Institute of Johns Hopkins University (Maryland, USA)
- US National Institutes of Health [RO1AI099300, RO1AI089830]
- US Department of Defense [PC130767]
- Established Investigator Award from the Melanoma Research Alliance (Washington, USA)
- Roswell Park Alliance Foundation
- US National Cancer Institute [P30CA016056]
- National Natural Science Fund of China [81571564, 81522020]
- 863 Young Scientists Special Fund [SS2015AA020932]
- Natural Science Foundation of China [91442117]
The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (T-reg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of Treg cells, and FOXP3 is centrally involved in the establishment and maintenance of the Treg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.
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