期刊
CARBOHYDRATE POLYMERS
卷 175, 期 -, 页码 557-564出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.08.020
关键词
Triple crosslinked; Injectable hydrogel; Scaffold; Cranial bone repaira
资金
- National Natural Science Foundation of China [51273086, 51541304, 51503091]
- Ministry of Education of China [20130211110017]
- Fundamental Research Funds for the Central Universities [lzujbky-2016-212, lzujbky-2016-41, lzujbky-2016-ct05]
Bone disease is a public health problem around the word, and it is urgent to develop novel tissue engineering scaffolds for the complicated cranial bone regeneration. The present work developed a novel triple crosslinked polysaccharides based injectable hydrogel to composite bio-glass (BG) for cranial bone repair. Dynamic mechanical analysis showed the storage modulus (G') of the hydrogel reached to similar to 4000 Pa. While after compositing BG, G' exceeded 4500 Pa. The degradation behavior of the hydrogel is influenced by hydrogel composition, crosslinking methods and degradation environment. Through compositing BG for rat cranial bone repair, excellent bone regeneration effect was achieved (chunks of white new tissue was detected in the defected site, HE histopathological analysis confirmed the new tissue was bone tissue). Thus, the hydrogel is suitable as the carrier of BG for bone repair, demonstrating the prepared triple crosslinked hydrogel is potential for bone tissue engineering applications. (C) 2017 Elsevier Ltd. All rights reserved.
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