期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 95, 期 -, 页码 656-661出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.08.085
关键词
Aspirin; Cancer; Clinical research; Molecular mechanisms
资金
- National Natural Science Foundation of China [81202085]
- Gansu Province Outstanding Youth Foundation [1506RJDA296]
- China Postdoctoral Science Foundation [2017M613430]
Aspirin has been widely used as an antipyretic analgesic drug. More and more evidences have shown that aspirin may be play some role on anti-tumor. In this article, we reviewed the research history of aspirin in the treatment and prevention of cancer. Many epidemiological and clinical studies have shown that aspirin can reduce the risk of a variety of malignant tumors and reduce cancer mortality. In addition, we discuss the specific mechanisms of aspirin in the anti-tumor effects. It has been found that aspirin mainly depends on the COX pathway and non-COX pathway to inhibit tumor cell growth and to curb tumor development. In this article, clinical studies and anti-tumor mechanism studies published in recent years are reviewed.
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