Absorption, tissue distribution, metabolism, and elimination of decabrominated diphenyl ether (BDE-209) in rats after multi-dose oral exposure

Human and ecological risks of BDE-209 have drawn much attention, particularly with growing e-waste recycling activities in developing countries. To further address the issue of BDE-209 biotransformation, a laboratory-controlled study was conducted. Female Sprague-Dawley rats were dosed orally by gavage at a daily dose of 1 mg kg(-1) body weight for 7 d and a depuration period of 22 d, to characterize absorption, distribution, metabolism, and elimination dynamics of BDE-209 during multi-dose exposures simulating short-term oral exposure of e-waste workers. The concentrations of BDE-209 in all tissues increased exponentially during the 7-d exposure period, indicating that multi-dose exposure could lead to increased accumulation of BDE-209 in rats. The liver accumulated the greatest amount of BDE-209 on a wet-weight basis, while adipose tissue had the highest concentration by the end of the 22-d depuration period. Halflives of BDE-209, 207, and 197 during depuration were 1.1 +/- 0.1, 2.7 +/- 03, and 10.5 +/- 3.1 d in serum and 0.9 +/- 0.1, 2.2 +/- 0.2, and 11.8 +/- 23 d in liver, i.e., the half-life increased with decreasing level of bromination from deca- to octa-BDEs and was similar in both serum and liver. By contrast, the half-life of the debromination metabolite BDE-207 (21.7 +/- 7.7 d) was longer in small intestine than in serum and liver, suggesting slower depletion of BDE-209 metabolites in small intestine. The metabolism of BDE-209 was not responsible for the occurrence of low brominated BDE congeners and OH and MeO-PBDEs in human tissues. (C) 2017 Elsevier Ltd. All rights reserved.