A REVIEW ON SUBLINGUAL SPRAY: NOVEL DRUG DELIVERY SYSTEM

Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual dosage form is to be placed under the tongue and produce immediate systemic effect of enabling the drug absorbed directly through the mucosal lining of the mouth beneath the tongue which is very rich to vascular blood supply. Sublingual spray is useful when rapid onset of action is desired with better patient compliance than orally ingested tablets. In terms of permeability, the sublingual area is more permeable than the vocal area, and hence also than the palatal area. The sublingual spray is to be sprayed for faster onset of activity. The absorption of drugs through sublingual route is 3-10 times larger than that presented by oral route hence can be employed for emergency weather. As per formulation aspects, dose uniformity of sublingual film is a technical challenge. On the other hand, ease of administration is more in the case of spray as compared to film. The primary advantages of sublingual spray include elimination of first pass effect, rapid drug absorption, high efficacy, large surface area and many more. In this delivery scheme, drug directly goes to the arterial circulation by sublingual vein and capillaries and then into the jugular vein and then to the Superior vena cava.