期刊
ATHEROSCLEROSIS
卷 266, 期 -, 页码 64-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2017.08.025
关键词
Epidemiology; Abdominal aortic aneurysm; Aortic dissection; Mortality; Alcohol; Risk factor
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022, 18014011, 20014026, 20390156]
- Osaka University Faculty of Medicine
- Comprehensive Research on Cardiovascular and Life-Style Related Diseases [H26-Junkankitou Seisaku-Ippan-001]
Background and aims: Only a few population-based prospective studies have examined the association between alcohol consumption and abdominal aortic aneurysm, and the results are inconsistent. Moreover, no evidence exists for aortic dissection. We examined the effect of alcohol consumption on risk of mortality from aortic diseases. Methods: A total of 34,720 men from the Japan Collaborative Cohort study, aged 40-79 years, without history of cardiovascular disease and cancer at baseline 1988 and 1990 were followed up until the end of 2009 for their mortality and its underlying cause. Hazard ratios of mortality from aortic diseases were estimated according to alcohol consumption categories of never-drinkers, ex-drinkers, regular drinkers of <= 30 g, and > 30 g ethanol per day. Results: During the median 17.9-year follow-up period, 45 men died of aortic dissection and 41 men died of abdominal aortic aneurysm. Light to moderate drinkers of <= 30 g ethanol per day had lower risk of mortality from total aortic disease and aortic dissection compared to never-drinkers. The respective multivariable hazard ratios (95% confidence intervals) were 0.46 (0.28-0.76) for total aortic disease and 0.16 (0.05-0.50) for aortic dissection. Heavy drinkers of > 30 g ethanol per day did not have reduced risk of mortality from total aortic disease, albeit had risk variation between aortic dissection and abdominal aortic aneurysm. Conclusions: Light to moderate alcohol consumption was associated with reduced mortality from aortic disease among Japanese men. (C) 2017 Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据