期刊
BIOCHIMIE
卷 142, 期 -, 页码 1-10出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2017.07.016
关键词
TMPRSS2; Influenza virus; Coronavirus; Therapeutics
资金
- National Natural Science Foundation of China [21572207]
- Program of International S T Cooperation [2015DFG32530]
- Zhejiang Provincial Natural Science Foundation of China [LY16160003]
Influenza virus and coronavirus epidemics or pandemics have occurred in succession worldwide throughout the early 21st century. These epidemics or pandemics pose a major threat to human health. Here, we outline a critical role of the host cell protease TMPRSS2 in influenza virus and coronavirus infections and highlight an antiviral therapeutic strategy targeting TMPRSS2. (C) 2017 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
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