期刊
CANCER SCIENCE
卷 108, 期 11, 页码 2239-2247出版社
WILEY
DOI: 10.1111/cas.13391
关键词
Colorectal cancer; genome-wide association study; Japanese; single nucleotide polymorphism; 10p14
类别
资金
- CREST, Japan Science and Technology Agency (JST)
- Japan Society for the Promotion of Science (JSPS) [15H0912, 15H05707, 21591644, 21791295, 21791297, 215921014, 21679006]
- Funding Program for Next Generation World-Leading Researchers [LS094]
- New Energy and Industrial Technology Development Organization (NEDO) Technological Development for Chromosome Analysis
- Priority Issue on Post-K computer [hp170227, hp160219]
- Grants-in-Aid for Scientific Research [15K05577, 17K12773, 15H05912] Funding Source: KAKEN
Genome-wide association studies are a powerful tool for searching for disease susceptibility loci. Several studies identifying single nucleotide polymorphisms (SNP) connected intimately to the onset of colorectal cancer (CRC) have been published, but there are few reports of genome-wide association studies in Japan. To identify genetic variants that modify the risk of CRC oncogenesis, especially in the Japanese population, we performed a multi-stage genome-wide association study using a large number of samples: 1846 CRC cases and 2675 controls. We identified 4 SNP (rs7912831, rs4749812, rs7898455 and rs10905453) in chromosome region 10p14 associated with CRC; however, there are no coding or non-coding genes within this region of fairly extensive linkage disequilibrium (a 500-kb block) on 10p14. Our study revealed that the 10p14 locus is significantly correlated with susceptibility to CRC in the Japanese population, in accordance with the results of multiple studies in other races.
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