期刊
ACS NANO
卷 11, 期 11, 页码 11337-11349出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b05858
关键词
electrospinning; biomaterials; skin cancer therapy; wound healing; tissue engineering
类别
资金
- National Key Research and Development Program of China [2016YFC1100201]
- CAS [QYZDB-SSW-SYS027]
- Science and Technology Commission of Shanghai Municipality [16DZ2260600]
Surgical excision of skin cancers can hardly remove the tumor tissues completely and simultaneously result in cutaneous defects. To avoid tumor recurrence and heal the tumor-induced wounds, we designed a tissue engineering membrane possessing bifunctions of tumor therapy and skin tissue regeneration. The micropatterned nanocomposite membrane was successfully fabricated by incorporating Cu2S nanoflowers into biopolymer fibers via a modified electrospinning method. With uniformly embedded Cu2S nanoparticles, the membranes exhibited excellent and controllable photothermal performance under near-infrared irradiation, which resulted in high mortality (>90%) of skin tumor cells and effectively inhibited tumor growth in mice. Moreover, the membranes supported the adhesion, proliferation, and migration of skin cells as well as significantly stimulated angiogenesis and healed full-thickness skin defects in vivo. This proof-of-concept study offers a facile and reliable strategy for localized skin tumor therapy and tissue regeneration using bifunctional tissue engineering biomaterials, showing great promise for tumor-induced wound healing applications.
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