期刊
CANCER LETTERS
卷 408, 期 -, 页码 112-120出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.08.030
关键词
RNA methylation; N-6-methyladenosine; m(6)A; Human cancers; Cancer therapy
类别
资金
- National Natural Science Foundation of China [81372321, 81472200, 81572261]
- Innovation Capability Development Project of Jiangsu Province [BM2015004]
- Project of Jiangsu Provincial Medical Talent [ZDRCA2016033]
- Key Project of Cutting-edge Clinical Technology of Jiangsu Province [BE2016797]
Reversible methylation by means of N6-methyladenosine (m(6)A) is the most prevalent internal modification in mammalian mRNA. This RNA chemical mark is created by proteins that are m(6)A writers and can be reversed by proteins that are m(6)A erasers (i.e., demethylases). Some other proteins serving as readers can recognize m(6)A-containing mRNA and regulate downstream molecular mechanisms accordingly. Although m(6)A bases in RNA perform critical functions in important biological processes, their roles in cancer biology and cancer stem cells remain largely unknown. In this review, we focus on the m(6)A-associated mechanisms and modification landscapes in several major malignant tumors. Global and detailed analyses were both conducted on relevant high-throughput sequencing data. Possible interventions against m(6)A demethylases are also explored in this review, which may be advantageous for the treatment of m(6)A related cancers. (C) 2017 Elsevier B.V. All rights reserved.
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