期刊
WATER RESEARCH
卷 124, 期 -, 页码 654-662出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.watres.2017.08.018
关键词
Brown trout; Contamination; Sewage water; Antidepressant; Real exposure
资金
- Ministry of Education, Youth and Sports of the Czech Republic
- project CENAKVA [CZ.1.05/2.1.00/01.0024]
- CENAKVA II under NPU I program [LO1205]
- Grant Agency of USB [012/2016/Z]
- Czech Science Foundation [15-04258S]
The treated effluent from sewage treatment plants (STP) is a major source of active pharmaceutical ingredients (APIs) that enter the aquatic environment. Bioaccumulation of 11 selected psychoactive pharmaceuticals (citalopram, clomipramine, haloperidol, hydroxyzine, levomepromazine, mianserin, mirtazapine, paroxetine, sertraline, tramadol and venlafaxine) was examined in Zivny Stream (tributary of the Blanice River, the Czech Republic), which is a small stream highly affected by effluent from the Prachatice STP. Six of the 11 pharmaceuticals were detected in grab water samples and in passive samplers. All pharmaceuticals were found in fish exposed to the stream for a defined time. The organs with highest presence of the selected pharmaceuticals were the liver and kidney; whereas only one pharmaceutical (sertraline) was detected in the brain of exposed fish. Fish plasma and muscle samples were not adequate in revealing exposure because the number of hits was much lower than that in the liver or kidney. Using the criterion of a bioaccumulation factor (BAF) >= 500, citalopram, mianserin, mirtazapine and sertraline could be classified as potential bioaccumulative compounds. In combination, data from integrative passive samplers and fish liver or kidney tissue samples were complimentary in detection of target compounds and simultaneously helped to distinguish between bioconcentration and bioaccumulation.(C) 2017 Elsevier Ltd. All rights reserved.
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