期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 13, 期 11, 页码 1457-1467出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2017.2446
关键词
Photothermal Therapy; Hyaluronic Acid; Platinum Nanoparticles; Tumor Targeting; Breast Cancer
资金
- National Natural Science Foundation of China [81671822]
- Shanghai Pujiang Program [14PJD016]
Targeted photothermal therapy (PTT) can improve the therapeutic outcomes and reduce side effects in cancer treatment. However, additional functionality means additional synthetic steps, increased risk of toxicity and complex behavior and effects in vivo. Herein, we developed a one-pot method to prepare tumor-targeted photothermal nanoparticles. Hyaluronic acid (HA), an anionic glycosaminoglycan that targets tumors via overexpressed cluster determinant 44 (CD44), was used as a polymer stabilizer to synthesize HA-encapsulated platinum nanoparticles (HA/Pt). The in vitro experiments demonstrated that HA/Pt were more efficiently internalized by cancer cells overexpressing CD44 compared with the nontumor targeting alginate acid-encapsulated Pt nanoparticles (AA/Pt). The in vivo studies revealed that HA/Pt accumulated more in CD44-overexpressing tumor than AA/Pt, and more efficiently inhibited tumor growth via PTT. Our study developed an innovative method for facile fabrication of tumor-targeting photothermal nanoparticles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据