期刊
CARDIOVASCULAR PATHOLOGY
卷 31, 期 -, 页码 47-53出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.carpath.2017.06.008
关键词
Chronic intermittent hypoxia; Tanshinone IIA; Endothelial dysfunction
资金
- National Natural Science Foundation of China [30971195, 81170069]
- Hebei Education Department Foundation [ZD2014043, ZD2014005, ZD2015026]
- Hebei Province Natural Science Foundation [C2011206031, C2009001053]
Chronic intermittent hypoxia (CIH) during repetitive airflow cessations may cause endothelial dysfunction. Tanshinone IIA (Tan IIA) has been used to treat various circulatory disturbance-related diseases because of its pharmacological actions, including vasodilation. However, the mechanism of the effect of its vasodilation is not well established. The objective of this study was to explore the effect of Tan IIA in endothelium-dependent contracting factors and endothelin receptors in aortic endothelial dysfunction in CIH rats. Aortas of rats were retrieved for use in in vitro experiments (isometric force measurement), histological analysis, immunohistochemistry, and Western blotting. Tan IIA treatment increased the expression of endothelial nitric oxide synthase (eNOS) and formation of nitric oxide (NO), inhibited the production of endothelin-1 (ET-1), down-regulated ETA receptor expression, and up-regulated ETB receptor expression. In conclusion, Tan IIA protects endothelial function by inhibiting strain-induced ET-1 expression, decreasing ETA receptors, increasing ETB receptors, increasing the formation of NO, and up-regulating eNOS in CIH. (C) 2017 Elsevier Inc. All rights reserved.
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