期刊
BIORESOURCE TECHNOLOGY
卷 244, 期 -, 页码 1198-1206出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2017.05.170
关键词
Microalgae; Stressful conditions; Multi-omics analyses; Genetic engineering; Biorefinery
资金
- National Natural Science Foundation of China [21536006]
Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance. (c) 2017 Elsevier Ltd. All rights reserved.
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