期刊
ALZHEIMERS & DEMENTIA
卷 11, 期 2, 页码 184-194出版社
WILEY
DOI: 10.1016/j.jalz.2013.03.001
关键词
Hippocampus; Hippocampal atrophy; Hippocampal volumetry; Manual segmentation protocol; Harmonization; Anatomic landmark; Alzheimer's disease; Manual tracing; Medial temporal lobes; Atrophy; Degeneration; Magnetic resonance; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Standard operating procedures
资金
- Wyeth, part of the Pfizer group
- Lilly
- Alzheimer's Association [IIRG -10-174022]
- ADNI (National Institutes of Health) [U01 AG024904]
- National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering
- Abbott
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Amorfix Life Sciences Ltd.
- AstraZeneca
- Bayer Health Care
- BioClinica, Inc.
- Biogen Idec Inc.
- Bristol-Myers Squibb Company
- Eisai Inc.
- Elan Pharmaceuticals Inc.
- Eli Lilly and Company
- F. Hoffmann-La Roche Ltd, company Genentech, Inc.
- GE Healthcare
- Innogenetics, N.V.
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Medpace, Inc.
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Servier
- Synarc Inc.
- Takeda Pharmaceutical Company
- Canadian Institutes of Health Research
- National Institutes of Health [P30 AG010129, K01 AG030514]
- Ministere du Developpement Economique, de l'Innovation et de l'Exportation du Quebec
Background: Hippocampal volumetry on magnetic resonance imaging is recognized as an Alzheimer's disease (AD) biomarker, and manual segmentation is the gold standard for measurement. However, a standard procedure is lacking. We operationalize and quantitate landmark differences to help a Delphi panel converge on a set of landmarks. Methods: One hundred percent of anatomic landmark variability across 12 different protocols for manual segmentation was reduced into four segmentation units (the minimum hippocampus, the alveus/fimbria, the tail, and the subiculum), which were segmented on magnetic resonance images by expert raters to estimate reliability and AD-related atrophy. Results: Intra- and interrater reliability were more than 0.96 and 0.92, respectively, except for the alveus/fimbria, which were 0.86 and 0.77, respectively. Of all AD-related atrophy, the minimum hippocampus contributed to 67%; tail, 24%; alveus/fimbria, 4%; and the subiculum, 5%. Conclusions: Anatomic landmark variability in available protocols can be reduced to four discrete and measurable segmentation units. Their quantitative assessment will help a Delphi panel to define a set of landmarks for a harmonized protocol. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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