期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 40, 页码 12137-12141出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201704744
关键词
C-H activation; cobalt catalysis; heterocycles; reaction mechanisms; structure elucidation
资金
- CERCA Programme/Generalitat de Catalunya
- Spanish Ministry of Economy, Industry and Competitiveness [MINECO: CTQ2016-79942-P]
- Spanish Ministry of Economy, Industry and Competitiveness (AIE/FEDER)
- Spanish Ministry of Economy, Industry and Competitiveness (EU)
- Spanish Ministry of Economy, Industry and Competitiveness (Severo Ochoa Excellence Accreditation) [SEV-2013-0319]
- ICIQ
Despite Cp*Co-III catalysts having emerged as a very attractive alternative to noble transition metals for the construction of heterocyclic scaffolds through C-H activation, the structure of the reactive species remains uncertain. Herein, we report the identification and unambiguous characterization of two long-sought cyclometalated Cp*Co-III complexes that have been proposed as key intermediates in C-H functionalization reactions. The addition of MeCN as a stabilizing ligand plays a crucial role, allowing the access to otherwise highly reactive species. Mechanistic investigations demonstrate the intermediacy of these species in oxidative annulations with alkynes, including the direct observation, under catalytic conditions, of a previously elusive post-migratory insertion seven-membered cobaltacycle.
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