期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 40, 页码 12052-12063出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701065
关键词
chemical biology; drug discovery; inhibitors; RNA splicing; spliceosome
资金
- Lymphoma Research Foundation [285871]
- NIH [PO1-CA081534]
- Bennett Family Foundation
- NIGMS/NIH Award [K12 GM068524]
Since its discovery in 1977, the study of alternative RNA splicing has revealed a plethora of mechanisms that had never before been documented in nature. Understanding these transitions and their outcome at the level of the cell and organism has become one of the great frontiers of modern chemical biology. Until 2007, this field remained in the hands of RNA biologists. However, the recent identification of natural product and synthetic modulators of RNA splicing has opened new access to this field, allowing for the first time a chemical-based interrogation of RNA splicing processes. Simultaneously, we have begun to understand the vital importance of splicing in disease, which offers a new platform for molecular discovery and therapy. As with many natural systems, gaining clear mechanistic detail at the molecular level is key towards understanding the operation of any biological machine. This minireview presents recent lessons learned in this emerging field of RNA splicing chemistry and chemical biology.
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