期刊
CHEMBIOCHEM
卷 18, 期 18, 页码 1792-1796出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201700210
关键词
biocompatible reactions; bioconjugation; click chemistry; Paal-Knorr reaction; protein labeling
资金
- Xenobe Research Institute
- National Cancer Institute [CA186046]
The application of new chemical reactions in a biological context has advanced bioconjugation methods for both fundamental research and commercial arenas. Recent adaptations of reactions such as Huisgen 1,3-dipolar or Diels-Alder cycloadditions have enabled the labeling of specific residues in biomolecules by the attachment of molecules carrying azides, alkynes, or strained alkenes. Although these are fundamental tools, there is a need for the discovery of reactions that can label native proteins. We report herein the adaptation of the Paal-Knorr reaction to label lysine residues in proteins via pyrrole linkages.
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