期刊
BIOCHIP JOURNAL
卷 11, 期 3, 页码 246-254出版社
KOREAN BIOCHIP SOCIETY-KBCS
DOI: 10.1007/s13206-017-1310-0
关键词
Gold nanoislands; Solid matrix; LDI-ToF mass spectrometry; Amino acids; Localized surface plasmon resonance
资金
- Nano-Convergence Foundation - Ministry of Science, ICT and Future Planning (MSIP, Korea) [R201602210]
- Ministry of Trade, Industry and Energy (MOTIE, Korea), Industry Technology Development Program - Ministry of Trade, Industry and Energy (MOTE, Korea) [10063335]
- National Research Foundation of Korea [NRF2017R1A2B4004077, NRF-2017R1A2B2004398]
- National Research Foundation of Korea [R201602210] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Gold nanoislands chip were developed as a solid matrix for the analysis of small molecules using laser desorption/ionization time-of-flight (LDI-ToF) mass spectrometry substituting the organic matrices which usually produce strong noise at low mass to-charge ratio range (m/z <500). Gold nanoislands were simply prepared by (1) deposition of gold layer on highly P-doped silicon substrate followed by (2) heating. Physical properties-of the gold nanoislands were analyzed by scanning electron microscope (SEM), atomic force microscopy (AFM) analysis to characterize the morphology, diameter, thickness, and surface density of the nanoislands which were comparatively analyzed in conjunction with LDI-ToF mass spectrometry. In this work, optimal size of the nanoislands were selected for LDI-ToF mass spectrometry, and gold nanoislands chip were applied to the quantitative and simultaneous detection of small analytes (amino acids) with various chemical and physical properties (polar, nonpolar, acidic, and basic).
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