期刊
ALZHEIMERS & DEMENTIA
卷 11, 期 1, 页码 1-15出版社
WILEY
DOI: 10.1016/j.jalz.2014.07.003
关键词
Amyloid imaging; Positron emission tomography; Pittsburgh compound B; Centiloid scale; Standardize
资金
- National Institute on Aging [R37 AG025516, P01 AG025204, P50 AG005133, R01 AG034570, P01 A0026276, U19 AG032438]
- NATIONAL INSTITUTE ON AGING [UF1AG032438, U19AG032438, P50AG005133, P01AG026276, RF1AG025516, P01AG025204, P01AG003991, R37AG025516] Funding Source: NIH RePORTER
Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (<= 45 years) and typical Alzheimer's disease patients. The units of this scale have been named Centiloids. Basically, we describe a standard method of analyzing PiB PET data and then a method for scaling any nonstandard method of PIE PET analysis (or any other tracer) to the Centiloid scale. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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