期刊
ALZHEIMERS & DEMENTIA
卷 11, 期 9, 页码 1080-1089出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2014.09.002
关键词
Mild cognitive impairment (MCI); Alzheimer's disease; Dementia; Everyday function; Daily functioning; Instrumental activities of daily living; Informant-report; Self-report; Biomarkers; ADNI
资金
- Alzheimer's Disease Neuroimaging Initiative (ADNI
- National Institute of Health Grant ) [U01 AG024904]
- Alzheimer's Disease Neuroimaging Initiative-2 (ADNI-2)
- Alzheimer's Disease Neuroimaging Initiative Grand Opportunity (ADNI-GO)
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- BioClinica, Inc.
- Biogen Idec Inc.
- Bristol-Myers Squibb Company
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.
- GE Healthcare
- Innogenetics, N.V.
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Medpace, Inc.
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Synarc Inc.
- Takeda Pharmaceutical Company
- Canadian Institutes of Health Research
- NIH grants [P30 AG010129, K01 AG030514, R01AG19771, P30AG10133, P30 AG 10129, RO1 AG031252]
It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self-versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [F-18]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
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