期刊
VISUAL NEUROSCIENCE
卷 34, 期 -, 页码 -出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0952523817000098
关键词
Thalamus; Retinal ganglion cells; Retinogeniculate; Lateral geniculate nucleus; Intergeniculate leaflet
资金
- National Institutes of Health [EY021222, EY024712, AI124677]
- Brain and Behavior Research Foundation NARSAD Independent Investigator Award
- Virginia Tech Carilion Research Institute Medical Research Scholar fellowship
Often mislabeled as a simple relay of sensory information, the thalamus is a complicated structure with diverse functions. This diversity is exemplified by roles visual thalamus plays in processing and transmitting light-derived stimuli. Such light-derived signals are transmitted to the thalamus by retinal ganglion cells (RGCs), the sole projection neurons of the retina. Axons from RGCs innervate more than ten distinct nuclei within thalamus, including those of the lateral geniculate complex. Nuclei within the lateral geniculate complex of nocturnal rodents, which include the dorsal lateral geniculate nucleus (dLGN), ventral lateral geniculate nucleus (vLGN), and intergeniculate leaflet (IGL), are each densely innervated by retinal projections, yet, exhibit distinct cytoarchitecture and connectivity. These features suggest that each nucleus within this complex plays a unique role in processing and transmitting light-derived signals. Here, we review the diverse cytoarchitecture and connectivity of these nuclei in nocturnal rodents, in an effort to highlight roles for dLGN in vision and for vLGN and IGL in visuomotor, vestibular, ocular, and circadian function.
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