期刊
VIRUS RESEARCH
卷 235, 期 -, 页码 49-57出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2017.04.001
关键词
Human papillomavirus; Carcinogenesis; Immune response; Transgenic mouse models
类别
资金
- Laboratory for Process Engineering, Environment, Biotechnology and Energy - LEPABE [POCI-01-0145-FEDER-006939]
- FEDER funds through COMPETE - Programa Operacional Competitividade e Internacionalizacao (POCI)
- FCT - Fundacao para a Ciencia e a Tecnologia
- Portuguese Foundation for Science and Technology - Portuguese Government [SFRH/BPD/85462/2012]
- Social European Fund
For decades, research on the pathogenesis of papillomavirus-induced lesions, particularly of human papillomavirus (HPV) has relied on the use of animal models. Among these, HPV-transgenic mice are some of the most frequently employed. After some initial unsuccessful attempts, researchers have succeeded in targeting the expression of one or more HPV-16 oncogenes to squamous epithelia, closely mimicking the lesions observed in cancer patients. The present review describes the relevance and usefulness of these animal models in understanding the tumour-associated immune response and developing new preventive and therapeutic strategies for HPV-associated cancers. In particular, this review details the importance of transgenic mice for dissecting and modulating relevant aspects of the tumour-associated immune response. Other animal models for studying papillomaviral diseases are briefly mentioned, along with their respective advantages and limitations. HPV-transgenic mouse strains remain reliable, versatile and commodious, even if perhaps underestimated, animal models for studying HPV-induced multi-step carcinogenesis.
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