期刊
VIRUS RESEARCH
卷 231, 期 -, 页码 76-82出版社
ELSEVIER
DOI: 10.1016/j.virusres.2016.12.006
关键词
Brd4; Papillomavirus life cycle; E2 protein; Papillomavirus replication; Papillomavirus transcription
类别
资金
- National Institutes of Health [CA103867]
- Cancer Prevention Research Institute of Texas [RP110471, RP140367]
- Welch Foundation [I-1805]
- German research Foundation (DFG) [SFB 773 B4]
Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. Papillomaviruses (PVs) have evolved to hijack Brd4's activity in order to create a facilitating environment for the viral life cycle. Brd4, in association with the major viral regulatory protein E2, is involved in multiple steps of the PV life cycle including replication initiation, viral gene transcription, and viral genome segregation and maintenance. Phosphorylation of Brd4, regulated by casein kinase II (CK2) and protein phosphatase 2A (PP2A), is critical for viral gene transcription as well as E1- and E2-dependent origin replication. Thus, pharmacological agents regulating Brd4 phosphorylation and inhibitors blocking phospho-Brd4 functions are promising candidates for therapeutic intervention in treating human papillomavirus (HPV) infections as well as associated disease. (C) 2016 Elsevier B.V. All rights reserved.
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