期刊
VIRUS RESEARCH
卷 234, 期 -, 页码 87-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2017.01.008
关键词
Paramyxovirus; Pneumovirus; Mononegavirales; Polymerase; Capping; Inhibitor
类别
资金
- The Hartwell Foundation
- NIH/NIAID [AI113321, AI011002, HD079327]
- NIH/NICHD
The paramyxo- and pneumoviruses are members of the order Mononegavirales, a group of viruses with non-segmented, negative strand RNA genomes. The polymerases of these viruses are multi-functional complexes, capable of transcribing subgenomic capped and polyadenylated mRNAs and replicating the genome. Although there is no native structure available for any complete paramyxo- or pneumovirus polymerase, functional and structural studies of a fragment of a pneumovirus polymerase protein and mutation analyses and resistance profiling of small-molecule inhibitors have generated a wealth of mechanistic information. This review integrates these data with the structure of a related polymerase, identifying similarities, differences, gaps in knowledge, and avenues for antiviral drug development. (C) 2017 Elsevier B.V. All rights reserved.
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