期刊
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
卷 1402, 期 1, 页码 31-42出版社
WILEY
DOI: 10.1111/nyas.13462
关键词
atherosclerosis; stem cells; diabetes; myelopoiesis
资金
- NIH [R01 DK095684, R01 HL117226, R01 HL084312]
- NHMRC [APP1083138, APP1106154, APP1085752]
- National Heart Foundation [100440]
Diabetes is the greatest risk factor for the development of cardiovascular disease, which, in turn, is the most prevalent cause of mortality and morbidity in diabetics. These patients have elevations in inflammatory monocytes, a factor consistently reported to drive the development of atherosclerosis. In preclinical models of both type 1 and type 2 diabetes, studies have demonstrated that the increased production and activation of monocytes is driven by enhanced myelopoiesis, promoted by factors, including hyperglycemia, impaired cholesterol efflux, and inflammasome activation, that affect the proliferation of bone marrow precursor cells. This suggests that continued mechanistic investigations of the enhanced myelopoiesis and the generation of inflammatory monocytes are timely, from the dual perspectives of understanding more deeply the underlying bases of diabetes pathophysiology and identifying therapeutic targets to reduce cardiovascular risk in these patients.
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