期刊
VIRUS RESEARCH
卷 242, 期 -, 页码 49-57出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2017.08.012
关键词
Metagenomics; Reoviridae; Viral discovery; Mosquito; Deep sequencing; Orbivirus
类别
资金
- Blood Systems Research Institute
- Grifols Diagnostic Solutions, Inc.
- NIH [HHSN272701000040I/HHSN2720004/D04, R24 AI 120942]
- Institute for Human Infections and Immunity
Eleven viral isolates derived mostly in albopictus C6/36 cells from mosquito pools collected in Southeast Asia and the Americas between 1966 and 2014 contained particles with electron microscopy morphology typical of reoviruses. Metagenomics analysis yielded the near complete genomes of three novel reoviruses, Big Cypress orbivirus, Ninarumi virus, and High Island virus and a new tetravirus, Sarawak virus. Strains of previously characterized Sathuvarachi, Yunnan, Banna and Parry's Lagoon viruses (Reoviridae), Bontang virus (Mesoniviridae), and Culex theileri flavivirus (Flaviviridae) were also characterized. The availability of these mosquito virus genomes will facilitate their detection by metagenomics or PCR to better determine their geographic range, extent of host tropism, and possible association with arthropod or vertebrate disease.
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