期刊
VIRUS RESEARCH
卷 231, 期 -, 页码 50-55出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2016.11.003
关键词
HPV E6; HPV E7; hTERT; Telomerase
类别
资金
- NCI NIH HHS [R01 CA172742] Funding Source: Medline
Telomerase extends the ends of linear chromosomes, and its expression leads to cellular immortalization. In HPV-associated cancers, telomerase is universally detected, and this occurs by activation of the catalytic subunit of telomerase, hTERT. The expression of hTERT is affected by both high-risk HPV E6 and E7. Seminal studies over the last two decades have identified the transcriptional, epigenetic, and post-transcriptional roles high-risk E6 and E7 have in telomerase regulation. This review will summarize these findings and highlight the importance of telomerase activation as an oncogenic pathway in HPV-associated cancer development and progression. (C) 2016 Elsevier B.V. All rights reserved.
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