期刊
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
卷 89, 期 3, 页码 1671-1681出版社
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765201720160908
关键词
antifungal; antioxidant; fatty acid methyl esters; vegetable oils
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86- 9.42 mu g/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6500 mu g/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 mu g/mL against Candida glabrata and C. krusei and 31.2 mu g/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
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