期刊
VIROLOGY
卷 507, 期 -, 页码 64-74出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2017.04.005
关键词
Adenovirus; Respiratory infection; CD8 T cells; Interferon gamma; Perforin
类别
资金
- University of Michigan Amendt-Heller Award [R01 AI083334, R21 AI103452]
- University of Michigan Charles Woodson Accelerator Award
CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in beta 2 m(-/-) mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in beta 2 m(-/-) mice. Virus induced weight loss and increases in bronchoalveolar lavage fluid total protein, IFN-gamma, TNF-alpha, IL-I0, CCL2, and CCL5 concentrations were less in beta 2 m(-/-) mice than in controls. CD8 T cell depletion had similar effects on virus clearance, weight loss, and inflammation. Deficiency of IFN-gamma or performn had no effect on viral replication or inflammation, but perforin-deficient mice were partially protected from weight loss. CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects.
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