期刊
VIRAL IMMUNOLOGY
卷 30, 期 8, 页码 622-626出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2017.0039
关键词
PML; JCPyV; BKPyV; natalizumab; multiple sclerosis
资金
- Biogen Idec (RPV)
To determine the association between BK polyomavirus (BKPyV) types 1 and 4 capsid antibody and natalizumab-associated progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS), serum samples were obtained from 10 natalizumab-associated PML cases and 130 control MS patients treated with natalizumab, and 82 control MS patients never exposed to natalizumab. In a sex- and age-adjusted regression model, BKPyV serotype 1 antibody levels were significantly higher in natalizumab-treated controls (p=0.009) compared with cases, and were higher in controls never treated with natalizumab compared with cases, but the difference did not reach statistical significance (p=0.158). There was no association between BKPyV serotype 4 antibody and PML. We hypothesize that a robust immune response to BKPyV may be protective against the development of PML.
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