期刊
NEOPLASMA
卷 64, 期 5, 页码 655-665出版社
AEPRESS SRO
DOI: 10.4149/neo_2017_502
关键词
glioma stern cells; radiosensitivity; signaling pathways
类别
资金
- National Natural Science Foundation of China [31570851, 81201742]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/beta-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR. Therefore, we seek to boost GSC radiosensitivity through activating or inactivating pathways alone or together to eliminate the likely source of glioma and prolong survival of patients.
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