期刊
BIOCHEMICAL PHARMACOLOGY
卷 141, 期 -, 页码 100-117出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2017.05.003
关键词
Vulnerability; Associative memory; Conditioned place preference; Withdrawal; Relapse
资金
- Spanish Ministry of Economy and Competitiveness (Agencia Estatal de Investigacion)
- European Research Development Fund (AEI/FEDER, UE) [PSI2015-73156-JIN, PSI2013-44901-P]
- Red de Trastornos Adictivos [RD16/0017/0001]
- Spanish Ministry of Education, Culture and Sports (FPU) [FPU13/04819]
- National System of Health-Instituto de Salud Carlos-III [CP14/00173, CP12/03109, CP14/00212]
After discovering that addictive drugs alter adult neurogenesis, the potential role of adult-born hippocampal neurons in drug addiction has become a promising research field, in which cocaine is the most frequently investigated drug. Although a substantial amount of pre-clinical evidence has accumulated, additional studies are required to reveal the mechanisms by which cocaine modulates adult hippocampal neurogenesis (AHN) and determine whether these adult-born neurons have a role in cocaine-related behaviors, such as cocaine-mediated cognitive symptoms. First, this review will summarize the cocaine-induced alterations in a number of neurobiological factors (neurotransmitters, neurotrophins, glucocorticoids, inflammatory mediators) that likely regulate both hippocampal-dependent learning and adult hippocampal neurogenesis after cocaine exposure. A separate section will provide a detailed review of the available literature that challenges the common view that cocaine reduces adult hippocampal neurogenesis. In fact, cocaine has a short-term anti-proliferative role, but the young adult-born neurons are apparently spared, or even enhanced, following certain cocaine protocols. Thus, we will try to reconcile this evidence with the hippocampal-dependent cognitive symptoms that are typically observed in cocaine addicts, and we will propose new directions for future studies to test the relevant hypothesis. Based on the evidence presented here, the regulation of adult hippocampal neurogenesis might be one of the many mechanisms by which cocaine sculpts hippocampus-dependent learning. (c) 2017 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据