期刊
EUROPEAN HEART JOURNAL
卷 36, 期 39, 页码 2643-2649出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehv308
关键词
Sitting; Standing; Isotemporal; Cross-sectional; Adult; Cardio-metabolic
资金
- National Health and Medical Research Council of Australia [566940, 1057608, 1003960, 1078360]
- Heart Foundation Postdoctoral Fellowship [PH 12B 7054]
- Victorian Government's OIS Program
- National Health and Medical Research Council (NHMRC) [233200, 1007544]
- Australian Government Department of Health and Ageing
- Abbott Australasia Pty Ltd
- Alphapharm Pty Ltd
- Amgen Australia
- AstraZeneca
- Bristol-Myers Squibb
- City Health Centre-Diabetes Service-Canberra
- Department of Health and Community Services-Northern Territory
- Department of Health and Human Services-Tasmania
- Department of Health-New South Wales
- Department of Health-Western Australia
- Department of Health-South Australia
- Department of Human Services-Victoria
- Diabetes Australia
- Diabetes Australia Northern Territory
- Eli Lilly Australia
- Estate of the Late Edward Wilson
- GlaxoSmithKline
- Jack Brockhoff Foundation
- Janssen-Cilag
- Kidney Health Australia
- Marian FH Flack Trust
- Menzies Research Institute
- Merck Sharp Dohme
- Novartis Pharmaceuticals
- Novo Nordisk Pharmaceuticals
- Pfizer Pty Ltd
- Pratt Foundation
- Queensland Health
- Roche Diagnostics Australia
- Royal Prince Alfred Hospital
- Sydney
- Sanofi Aventis
- sanofi-synthelabo
Aims While excessive sitting time is related adversely to cardio-metabolic health, it is unknown whether standing is a suitable replacement activity or whether ambulatory movement is required. Using isotemporal substitution analyses, we modelled cross-sectional associations with cardio-metabolic risk biomarkers of reallocating time (2 h/day) from sitting to standing or to stepping. Methods and results A subsample of participants from the 2011/12 Australian Diabetes, Obesity, and Lifestyle Study wore the posture-based activPAL3 monitor [36-80 years (mean 57.9, SD 9.9 years); 57% women; n = 698 with data]. Associations of activPAL3-derived mean daily time sitting/lying (sitting), standing and stepping with body mass index (BMI), waist circumference, blood pressure, HbA1c, fasting glucose and lipids (high-density lipoprotein-, HDL, and low-density lipoprotein-cholesterol, total/HDL-cholesterol ratio, and triglycerides), and 2-h plasma glucose were examined. Adjusted for relevant confounders, sitting-to-standing reallocations were only significantly (P < 0.05) associated with approximately 2% lower fasting plasma glucose, 11% lower triglycerides, 6% lower total/HDL-cholesterol ratio, and 0.06 mmol/L higher HDL-cholesterol per 2 h/day. Sitting-to-stepping reallocations were only significantly associated with approximately 11% lower BMI, 7.5 cm lower waist circumference, 11% lower 2-h plasma glucose, 14% lower triglycerides, and 0.10 mmol/L higher HDL-cholesterol per 2 h/day, while standing-to-stepping reallocations were only significantly associated with similar to 10% lower BMI, 7 cm lower waist circumference, and 11% lower 2-h plasma glucose. Conclusion Findings suggested that sitting-reduction strategies targeting increased standing, stepping, or both, may benefit cardio-metabolic health. Standing is a simple alternative to sitting, and requires further examination in prospective and intervention studies.
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