期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 85, 页码 11622-11633出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc06442j
关键词
-
资金
- Beneficentia Stiftung (Vaduz, Liechtenstein)
- Fondazione Cassa Risparmio di Firenze (CRF)
- AIRC [IG-16049]
- University of Naples Federico II [000005-ALTRI_DR_409_2017_Rec_Ateneo]
The combined use of X-ray crystallography and mass spectrometry represents a valuable strategy to investigate and characterize protein metalation induced by anticancer metal-based drugs. Here, we summarize a series of significant results recently obtained in our laboratories upon the examination of the structures of several adducts of proteins with representative metallodrugs (mostly containing ruthenium, gold and platinum). The general mechanisms of protein metalation that emerge from a careful comparative analysis of these structures are illustrated and their mechanistic implications are discussed. Possible directions for future work in the field are delineated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据