期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 45, 页码 14212-14216出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201706554
关键词
alkyl radicals; allylic synthons; Heck reaction; palladium; photocatalysis
资金
- National Institutes of Health [GM120281]
- National Science Foundation [CHE-1663779]
The first visible light-induced Pd-catalyzed Heck reaction of a-heteroatom substituted alkyl iodides and - bromides with vinyl arenes/heteroarenes has been developed. This transformation efficiently proceeds at room temperature and enables synthesis of valuable functionalized allylic systems, such as allylic silanes, boronates, germanes, stannanes, pivalates, phosphonates, phthalimides, and tosylates from the corresponding a-substituted methyl iodides. Notably, synthesis of the latter substrates failed under existing thermally induced Pd-catalyzed conditions, which highlights the importance of visible light for this transformation.
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