期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 46, 页码 14400-14404出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201704430
关键词
anticancer; anti-Stokes shifts; BODIPY; prodrug activation; triplet-triplet annihilation upconversion
资金
- National Institutes of Health [R01MH103133]
- Human Frontier Science [RGY-0090/2014]
- UMass OTCV
A strategy to expand anti-Stokes shifting from the far-red to deep-blue region in metal-free triplet-triplet annihilation upconversion (TTA-UC) is presented. The method is demonstrated by in vivo titration of the photorelease of an anticancer prodrug. This new TTA system has robust brightness and the longest anti-Stokes shift of any reported TTA system. TTA core-shell-structured prodrug delivery capsules that benefit from these properties were developed; they can operate with low-power density far-red light-emitting diode light. These capsules contain mesoporous silica nanoparticles preloaded with TTA molecules as the core, and amphiphilic polymers encapsulating anticancer prodrug molecules as the shell. When stimulated by far-red light, the intense TTA upconversion blue emission in the system activates the anticancer prodrug molecules and shows effective tumor growth inhibition in vivo. This work paves the way to new organic TTA upconversion techniques that are applicable to in vivo photocontrollable drug release and other biophotonic applications.
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