期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 64, 页码 16162-16166出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201703584
关键词
biodynamers; dynamic proteoids; equilibrium polymerization; nanostructures; supramolecular chemistry
资金
- Chinese Scholarship Council
- Dutch Ministry of Education, Culture and Science (Gravitation Program) [024.001.035]
- Netherlands Organization for Scientific Research (VIDI grant)
Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar-containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide-based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.
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