期刊
EUROPEAN HEART JOURNAL
卷 37, 期 2, 页码 177-185出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehv456
关键词
Cohort studies; Propensity score; Multivariate analysis; Perioperative period; Surgical procedures; Statin
资金
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Ontario
- Academic Health Science Centres Alternative Funding Plan Innovation Fund
- McMaster University (CLARITY Group)
- McMaster University (Department of Clinical Epidemiology and Biostatistics)
- McMaster University (Department of PHRI)
- McMaster University (Department of Cardiology)
- McMaster University (Department of Surgery)
- McMaster University (Department of Surgical Associates Research)
- McMaster University (Department of Anesthesiology)
- McMaster University (Department of Medicine)
- Hamilton Health Sciences
- Hamilton Health Sciences Grant
- Ontario Ministry of Resource and Innovation Grant
- Stryker Canada
- Saint Joseph's Healthcare, Department of Medicine
- Father Sean O'Sullivan Research Centre
- Canadian Network and Centre for Trials Internationally
- Winnipeg Health Sciences Foundation Operating Grant
- University of Manitoba (University Medical Group)
- University of Manitoba (Department of Surgery)
- University of Manitoba (Department of Surgery GFT Research)
- University of Manitoba (Department of Faculty of Dentistry Operational Fund)
- University of Manitoba (Department of Anesthesia)
- Diagnostic Services of Manitoba Research
- Manitoba Medical Services Foundation Grant
- Manitoba Health Research Council
- Rudy Falk Clinician Scientist Award
- National Health and Medical Research Council Program
- Australian and New Zealand College of Anesthesiologists
- PROADI-SUS-Ministry of Health
- Public Policy Research Fund, Research Grant Council, Hong-Kong SAR
- School of Nursing, Universidad Industrial de Santander
- Grupo de Cardiologia Preventiva, Universidad Autonoma de Bucaramanga
- Fundacion Cardioinfantil-Instituto de Cardiologia
- Alianza Diagnostica S.A
- St. John's Medical College
- Research Institute Grant, Division of Clinical Research and Training Grant
- University of Malaya Research Grant
- University of Malaya, Penyelidikan Jangka Pendek Grant
- Instituto de Salud Carlos III, Fundacio La Marato de TV3
- American Heart Association Grant
- National Institute for Health Research
- National Institute for General Medical Sciences, NIH
- Washington University Institute of Clinical and Translational Sciences
Aims The aim of this study was to assess the effects of pre-operative statin therapy on cardiovascular events in the first 30-days after non-cardiac surgery. Methods and results We conducted an international, prospective, cohort study of patients who were >= 45 years having in-patient non-cardiac surgery. We estimated the probability of receiving statins pre-operatively using a multivariable logistic model and conducted a propensity score analysis to correct for confounding. A total of 15 478 patients were recruited at 12 centres in eight countries from August 2007 to January 2011. The matched population consisted of 2845 patients (18.4%) treated with a statin and 4492 (29.0%) controls. The pre-operative use of statins was associated with lower risk of the primary outcome, a composite of all-cause mortality, myocardial injury after non-cardiac surgery (MINS), or stroke at 30 days [relative risk (RR), 0.83; 95% confidence interval (CI), 0.73-0.95; P = 0.007]. Statins were also associated with a significant lower risk of all-cause mortality (RR, 0.58; 95% CI, 0.40-0.83; P = 0.003), cardiovascular mortality (RR, 0.42; 95% CI, 0.23-0.76; P = 0.004), and MINS (RR, 0.86; 95% CI, 0.73-0.98; P = 0.02). There were no statistically significant differences in the risk of myocardial infarction or stroke. Conclusion Among patients undergoing non-cardiac surgery, pre-operative statin therapy was independently associated with a lower risk of cardiovascular outcomes at 30 days. These results require confirmation in a large randomized trial.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据