期刊
CHEMBIOCHEM
卷 18, 期 21, 页码 2115-2118出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201700354
关键词
biosynthesis; convergent evolution; cyanobacteria; enzymes; sulfur
资金
- Swiss National Foundation
- European Research Council [ERC-2013-StG 336559]
- SSSTC
- CSC
Biosynthesis of N-alpha-trimethyl-2-thiohistidine (ergothioneine) is a frequent trait in cyanobacteria. This sulfur compound may provide essential relief from oxidative stress related to oxygenic photosynthesis. The central steps in ergothioneine biosynthesis are catalyzed by a histidine methyltransferase and an iron-dependent sulfoxide synthase. In this report, we present evidence that some cyanobacteria recruited and adapted a sulfoxide synthase from a different biosynthetic pathway to make ergothioneine. The discovery of a second origin of ergothioneine production underscores the physiological importance of this metabolite and highlights the evolutionary malleability of the thiohistidine biosynthetic machinery.
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