期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 61, 页码 15300-15304出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201703832
关键词
metal-free; quinoline; regioselectivity; synthesis; triflic anhydride
资金
- National Natural Science Foundation of China [NSF21472073, NSF21532001]
- 111 project
A concise, novel and flexible metal-free single step to synthesize functionalized quinolines is reported. Triflic anhydride-mediated (Tf2O) activation of amides is discussed in the presence of pyridine to offer strong electrophiles, thereby showcasing excellent productivity, high regio- and chemoselectivity, and widely tolerable substrates. This approach provides a straightforward and efficient way to construct azaheterocycle structures.
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