期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 74, 期 22, 页码 4077-4095出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2570-5
关键词
Primary ciliogenesis; Protein machinery; Fibroblasts; Polarized epithelial cells; Midbody remnant; Intracellular pathway; Alternative pathway
资金
- Ministerio de Economia y Competitividad MINECO, Spain [BFU2015-67266-R]
- Fondo Europeo de Desarrollo Regional (FEDER), European Union
- MINECO
Primary cilia are solitary, microtubule-based protrusions of the cell surface that play fundamental roles as photosensors, mechanosensors and biochemical sensors. Primary cilia dysfunction results in a long list of developmental and degenerative disorders that combine to give rise to a large spectrum of human diseases affecting almost any major body organ. Depending on the cell type, primary ciliogenesis is initiated intracellularly, as in fibroblasts, or at the cell surface, as in renal polarized epithelial cells. In this review, we have focused on the routes of primary ciliogenesis placing particular emphasis on the recently described pathway in renal polarized epithelial cells by which the midbody remnant resulting from a previous cell division event enables the centrosome for initiation of primary cilium assembly. The protein machinery implicated in primary cilium formation in epithelial cells, including the machinery best known for its involvement in establishing cell polarity and polarized membrane trafficking, is also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据