期刊
CHEMICAL PHYSICS LETTERS
卷 687, 期 -, 页码 44-53出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cplett.2017.08.066
关键词
-
资金
- Department of Science and Technology (DST), Government of India
- CSIR
In this letter, small amount of beer [0.42-2.08% (v/v)] is employed to investigate the fibril inhibition kinetics of 1 mM L-Phenylalanine and L-Tyrosine (relevant to disease condition) using Fluorescence Lifetime imaging Microscopy (FLIM), Field Emission Scanning Electron Microscopy (FESEM) and High Resolution Transmission Electron Microscopic (HR-TEM) techniques. Our results indicate that 1.67 and 0.42% of beer is sufficient for effective breakdown of L-Phe and L-Tyr assemblies, respectively. Quantitative information about fibril inhibition is obtained from Fluorescence Correlation Spectroscopic (FCS) measurements. We have shown that the morphology of L-Phe changes to L-Tyr in presence of 2,2'-Bipyridine-3,3'-diol (BP(OH)(2)). (C) 2017 Elsevier B.V. All rights reserved.
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