期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 27, 期 21, 页码 4828-4831出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2017.09.049
关键词
Sirt 1; Osteoporosis; Osteogeneration; Indazole; HTS
A series of indazole derivatives were identified as Sirt 1 activators though high-throughput screening. Optimization of each substituent on the indazole ring led to the identification of compound 13. Compound 13 appeared to give the best Sirt 1 activity of the compounds tested and also showed osteogenesis activity in a cell assay. Sirt 1 activators are therefore potential candidates for the treatment of (C) 2017 Elsevier Ltd. All rights reserved.
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