期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 23, 期 11, 页码 826-833出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2017.01.013
关键词
ESBL/AmpC; Carbapenemase; CTX-M; CMY; NDM; OXA-48; VIM; IMP; Animal; Food
资金
- French agency for food, environmental and occupational health safety (ANSES, France)
- Faculty of Science, University of Fribourg (Switzerland)
There has been a great and long-term concern that extended-spectrum beta-lactamase ( ESBL)/AmpC- and carbapenemase-producing Enterobacteriaceae occurring in animals may constitute a public-health issue. A large number of factors with complex interrelations contribute to the spread of those bacteria among animals and humans. ESBL/AmpC-or carbapenemase-encoding genes are most often located on mobile genetic elements favouring their dissemination. Some shared reservoirs of ESBL/AmpC or carbapenemase genes, plasmids or clones have been identified and suggest cross-transmissions. Even though exposure to animals is regarded as a risk factor, evidence for a direct transfer of ESBL/AmpC-producing bacteria from animals to humans through close contacts is limited. Nonetheless, the size of the commensal ESBL/AmpC reservoir in non-human sources is dramatically rising. This may constitute an indirect risk to public health by increasing the gene pool from which pathogenic bacteria can pick up ESBL/AmpC/carbapenemase genes. The extent to which food contributes to potential transmission of ESBL/AmpC producers to humans is also not well established. Overall, events leading to the occurrence of ESBL/AmpC- and carbapenemase-encoding genes in animals seem very much multifactorial. The impact of animal reservoirs on human health still remains debatable and unclear; nonetheless, there are some examples of direct links that have been identified. (C) 2017 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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