期刊
VASCULAR PHARMACOLOGY
卷 89, 期 -, 页码 12-18出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.vph.2016.11.008
关键词
Alzheimer's disease; blood-brain barrier; vascular disorders
资金
- Erasmus Mundus foundation
- European Neuroscience Campus (ENC) joint doctoral fellowship
- ZonMW Memorabel program [733050105]
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people worldwide. One of the prominent causative factors of AD pathogenesis is cerebral vascular dysfunction, which results in diminished cerebral perfusion. Moreover, due to the loss of the protective function of the blood-brain barrier (BBB), impaired clearance of excess neurotoxic amyloid beta (A beta) occurs, causing vascular perturbation and diminished cognitive functioning. The relationship between the prevalence of AD and vascular risk factors is complex and not fully understood. In this review we illustrate the vascular risk factors, their effects on BBB function and their contributions to the onset of AD. Additionally, we discuss the underlying factors that may lead to altered neurovascular function and/or cerebral hypoperfusion in AD. (C) 2016 Elsevier Inc. All rights reserved.
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